Fulltext – Transdermal Drug Delivery System of Aceclofenac for Rheumatoid Arthritis An ideal transdermal patch should have flexibility, elasticity and softness. Formulation and biopharmaceutical evaluation of a transdermal patch containing aceclofenac. Rhee YS(1), Nguyen T, Park ES, Chi SC. transdermal matrix type patches to sustain its release characteristics. Key Words: Aceclofenac, Transdermal drug delivery, HPMC, Ethyl.

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Preparation of aceclofenac transdermal films: Ex vivo permeation study: Samples withdrawn were then analysed for their absorbance In-Vitro Permeation Studies: Both the enhancers increased the permeation to greater extent as compared to the film without any enhancer.

Formulation and biopharmaceutical evaluation of a transdermal patch containing aceclofenac.

The author is thankful to significant variation. Drug Dev Ind Pharm. The variation in length indicates the nonuniformity in flatness.

A nonionic surfactant-Span and a terpene d limonene were taken as enhancers. Different concentrations of oleic acid and isopropyl myristate were used to enhance the transdermal permeation of Aceclofenac.

Formulation and biopharmaceutical evaluation of a transdermal patch containing aceclofenac.

In some previous studies d-limonene has been reported to be the very promising penetration enhancer Yang et al. User Username Password Remember me. The prepared transdermal films were subjected to physicochemical evaluations, ex vivo permeation and in vivo anti-inflammatory studies.

In the present study, the transdermal films of aceclofenac were prepared and the effect of two permeation enhancers in increasing the flux of the drug was studied. Formulation prepared with hydrophilic polymer containing permeation enhancer showed best in-vitro skin permeation through rat skin Wistar albino rat as compared to all other formulations. The percentage of moisture content was calculated as the difference between initial and final weight with respect to final weight.


The films prepared with permeation enhancer F2 to F5 showed greater percent drug release at the end of 24 h Fig. Aceclofenac, Transdermal Film, Permeation enhancer, In-vitro permeation study. The percentage flatness was calculated as:. Skin permeation of propranolol from polymeric film containing terpene enhancers for transdermal use, Int. After complete drying, the transdermal patches of 20 mm diameter were cut, wrapped in aluminum foil and stored in desiccator till further evaluation.

Solution was then filtered and drug specific time interval and equal amount of phosphate content was estimated spectrophotometrically at buffer was replaced each time to maintain volume of nm after suitable dilution. Percentage of moisture content was found to be in the range of 1. After 12 h of shaving, non-medicated patch was applied to the group I control using an adhesive tape USP.

Skip to main content. To the group IV standard 0. Stability of a TDDS is a very important Formulation was also characterised for other factor to be considered while formulating such system parameters like physical appearance and physical because it affects therapeutic efficacy of the system as parameters and drug content uniformity.

Breaking the barriers of drug permeation via the skin. The permeation enhancement effect was found to be dominant with d-limonene as compared to Span Pain treatment in arthritis-related pain: The tensile following formula. The rats were allowed free access to drinking water and standard diet. The drug and all the excipients were found to be compatible on the basis of TLC studies.

The performance of the prepared films with enhancer was compared with that of one without the enhancer. Controlled and Novel Drug Delivery. In-vitro permeation studies of formulations were performed by using Franz transdermap cells.

Methods for the study of irritation and toxicity of substances applied topically to the skin and mucous membranes. Transddrmal and in-vitro characterization. The percentage of drug content was found to be in the range of Effect of penetration enhancers on flurbiprofen permeation though rat skin.


Effects of diclofenac, aceclofenac and meloxicam on the metabolism of proteoglycans and hyaluronan in osteoarthritic human transdrmal. Help Center Find new research papers in: Log In Sign Up. The mean value of three readings and standard deviation of folding endurance the number of times, the film could be folded at the same place without breaking were shown in Table 2.

Drug solution castor oil. Design and evaluation of matrix diffusion controlled transdermal patches of verapamil hydrochloride, Drug Dev. Longitudinal strips were cut from each film from three different location of the each film. Remember me on this computer. Both the formulations were found to be non-irritant to the skin because it showed erythema and edema score less than 2 Mamatha et al. Drug release from compression molded films: The other side of cellulose nitrate membrane was towards the Drug Content Uniformity: Pharm Pharmaceutic Sci, Volume 13 2 Transdermal science and technology: Result of all evaluation carried out in order to detect irritation and parameters was found to be satisfactory within sensitization under conditions of maximal stress which permissible limits.

The polymer solution thus obtained was ratio.

The average in percentage of drug contents of three films was noted. Formulation F9 showed highest flux among all the formulations and 1.

Weights required to break the which on a large part determines patient acceptability patch was noted.