En la esclerosis sistémica, el esófago se afecta en un 90%, seguido de los tramos anorrectal (%), gástrico ( 70%), colon (%) e intestino delgado. La esclerodermia es un relativamente infrecuente enfermedad reumática autoinmunitaria que afecta la piel y otros órganos del cuerpo. La esclerosis sistémica es una enfermedad autoinmune del tejido conectivo, que se caracteriza por un depósito excesivo de tejido colágeno y otros.

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Morphologic changes in the digital arteries of patients with progressive systemic sclerosis and Raynaud phenomenon. Clinical significance of fibromyalgia syndrome in different Rheumatology, 10pp. Hospital de Especialidades Dr. Arthritis Rheum, 36pp.

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Br J Rheumatol, 37pp. Other abnormalities described in this disease include peripheral large vessels stiffness and secondary cardiac involvement due to pulmonary and systemic arterial hypertension. Nailfold capillaroscopy in the screening and diagnosis of Raynaud’s phenomenon.


Reversible cold-induced abnormalities in myocardial perfusion and function in systemic sclerosis. Botulinum toxin in the treatment of Raynaud’s phenomenon: J Assoc Acad Minor Phys, 4pp. Arthritis Rheum, 43pp. J Rheumatol, 6pp. Arthritis Rheum, 41pp.

Clin Pharmacol Ther, 47pp. These lesions are extremely painful, heal slowly and lead to substantial functional disability.

Preventive effect o fan oral prostacyclin analog, beraprost sodium, on digital necrosis in systemic sclerosis French microcirculation society multicenter group for the study of vascular acrosyndromes. However, ecocardiographic prevalence is 5. Curr Opin Rheumatol, 11pp. Double-blind, multicenter controlled trial comparing topical dimethyl sulfoxide and normal saline for treatment of hand ulcers in patients with systemic sclerosis.

Hemorragia por telangiectasias en paciente con esclerosis sistémica

Arthritis Rheum, 42pp. Endothelial cell apoptosis is a primary pathogenetic event underlying skin lesions in avian and human scleroderma.

Am Esclerosiz J, 95pp. J Intern Med,pp. Scleroderma pericardial disease presented with a large pericardial effusion -a case report. A controlled double-blind trial. Surgery of the hand in patients with systemic sclerosis: The natural history of systemic lupus erythematosus by prospective analysis. Alteration of arterial distensibility in systemic sclerosis.


Microvascular abnormalities as possible predictors of disease subset in Raynaud’s phenomenon and early connective tissue disease. Circulation,pp. The pathogenesis of digital ulcers differs depending on their location and occurs in up to half of all patients with limited or diffuse sistfmica sclerosis at some point during their disease.

Tratamiento de la esclerosis sistémica | Reumatología Clínica

Scleroderma, fibroblasts, signaling, and excessive extracellular matrix. Serotonin reuptake inhibitors in Raynaud’s phenomenon. Continuing navigation will be considered as acceptance of this use. Rheumatology, 42pp.